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January 1, 1972The Journal of AntibioticsOpen Access

DOPAMINE β-HYDROXYLASE INHIBITOR PRODUCED BY GLOEOPHYLLUM STRIATUM AND ITS IDENTITY WITH OOSPONOL

HAMAO UMEZAWA HIRONOBU IINUMA Manabu Ito MEIKI MATSUZAKI T Takeuchi Osamu Tanabe

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Abstract

A dopamine β-hydroxylase inhibitor produced by Gloeophyllum striatum was isolated and found to be identical with oosponol. The inhibition is competitive with tyramine and noncompetitve with ascorbic acid. This inhibitor showed a hypotensive effect.

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UMEZAWA et al. (1972) studied this question.

synapsesocial.com/papers/6a87b925f74a0b9536e957c5 https://doi.org/10.7164/antibiotics.25.239

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