Map reading: Alkylation of a 15-base-pair double-stranded oligonucleotide modified with the carcinogen (±)-anti-benzo[a]pyrene diol epoxide (see picture) or N-hydroxy-4-aminobiphenyl is mapped by liquid chromatograhy–tandem mass spectrometry and collision-induced dissociation (CID). The method does not require prior DNA cleavage or hydrolysis.
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Chowdhury et al. (2007) studied this question.
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