Why the study?
Extracellular vesicles and their contents are altered in atrial fibrillation, but existing observations need thorough synthesis and confirmation in large trials.
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Extracellular vesicles and their contents, such as micro-RNAs, are altered in patients with atrial fibrillation, highlighting their potential role in the disease's pathophysiology and as biomarkers.
Extracellular vesicles are particles released from cells and delimited by a lipid bilayer. They have been widely studied, including extensive investigation in cardiovascular diseases. Many scientists have explored their role in atrial fibrillation. Patients suffering from atrial fibrillation have been evidenced to present altered levels of these particles as well as changed amounts of their contents such as micro-ribonucleic acids (miRs). Although many observations have been made so far, a large randomized clinical trial is needed to assess the previous findings. This review aims to thoroughly summarize current research regarding extracellular vesicles in atrial fibrillation.
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Procyk et al. (2022) studied this question.
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