Why the study?
Are plasma PDGF concentrations elevated in post-MI patients compared to angina patients and healthy controls?
Are plasma PDGF concentrations elevated in post-MI patients compared to angina patients and healthy controls?
Plasma PDGF concentrations are significantly elevated in post-MI patients compared to those with stable angina or healthy controls, suggesting a potential role in accelerated atherosclerosis progression.
Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28), angina patients (n = 25), and control subjects (n = 27). Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher in the post MI group compared to both the control and angina groups (P < or = 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF. High concentrations of PDGF in the circulation could further accelerate the progression of the disease.
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Wallace et al. (1998) studied this question.
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