We conducted a study to ascertain if an observed reduction of susceptibility to brodifacoum in Norway rats (Rattus norvegicus) present on at least 3 farms in Berkshire, United Kingdom, was heritable. This trait was demonstrated in individual rats by their survival after consumption of 0.0005% (m/m) bro difacoum in the diet for 7 days (Gill and MacNicoll 1991) and is termed «low grade» resistance. It is inherited through at least 5 generations and is not associated with vitamin K deficiency. Our data also suggest a different explanation for the inheritance of difenacoum resistance compared with that reported by Greaves and Cullen-Ayres (1988)
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Gill et al. (1992) studied this question.