Why the study?
Does trypsin cleavage of type 3 poliovirus alter its neutralization by sera from individuals immunized with inactivated versus live poliovirus vaccines or natural infection?
Population
Sera from children immunized solely with inactivated poliovirus vaccine, older persons exposed to natural…
Comparison
Incubation of type 3 poliovirus with human… vs Intact type 3 poliovirus
Design
Preclinical
Authors
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May explain IPV's weak mucosal immunity; leaves open whether trypsin-treated antigens merit testing in improved formulations.
Does trypsin cleavage of type 3 poliovirus alter its neutralization by sera from individuals immunized with inactivated versus live poliovirus vaccines or natural infection?
Trypsin cleavage of type 3 poliovirus in the gut alters its antigenic properties, which may explain the weak mucosal immunity of IPV and suggests incorporating trypsin-treated virus in IPV.
Roivainen et al. (1987) studied this question.
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