An immunochemical study of human urinary erythropoietin has been presented. The experiments indicate that the erythropoietic activity as assayed in the polycythemic mouse of erythropoietically active human urinary concentrates can be neutralized in vitro by addition of sera obtained from rabbits previously immunized with such concentrates. A significant depression of erythropoiesis was observed after injection of such sera into normal mice. It is concluded that neutralization is the result of an antigen-antibody reaction.
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Schooley et al. (1962) studied this question.