One‐Step Synthesis of Tröger's Base Hybrids Containing at Least One Halogen Atom

The one‐step synthesis of a series of hybrid dibenzo Tröger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46 %, together with the symmetric Tröger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi‐step approaches to hybrid Tröger's base compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)