Medical Management of Benign Prostatic Hyperplasia — Are Two Drugs Better Than One?

The prostate is a complex organ composed of epithelial cells and fibromuscular stroma. Benign prostatic hyperplasia is a true hyperplastic process, with an increase in the number of cells arising initially in the transition zone of the gland. Complex stromal–epithelial interactions lead to benign prostatic hyperplasia in 50 percent of men by the age of 50 years. This process requires testicular androgens and progresses with age. Aging is accompanied by an increase in symptoms of bladder obstruction or irritation attributable to benign prostatic hyperplasia. A prospective study showed that 24 percent of men with moderate symptoms of benign prostatic hyperplasia . . .