Erythrokinetics in Myxedema

Article1 September 1967Erythrokinetics in MyxedemaJOSEPH M. KIELY, M.D., F.A.C.P., DON C. PURNELL, M.D., F.A.C.P., CHARLES A. OWEN JR., M.D.JOSEPH M. KIELY, M.D., F.A.C.P.Search for more papers by this author, DON C. PURNELL, M.D., F.A.C.P.Search for more papers by this author, CHARLES A. OWEN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-533 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNormochromic anemia of modest degree is common in myxedematous patients and may persist for months after institution of thyroid hormone therapy (1-3). The bone marrow tends to be hypocellular (4). Most investigators have found the red blood cell survival to be normal and generally suspect that the anemia is due to decreased erythropoiesis.Iron deficiency anemia in women with myxedema is often due to menorrhagia and responds adequately to the administration of iron, without treatment of the hypothyroidism. Macrocytic anemia is usually due to the coexistence of pernicious anemia, which has a much higher prevalence in patients with myxedema than...References1. BOMFORD R: Anaemia in myxoedema: and the role of the thyroid gland in erythropoiesis. Quart. J. Med. 7: 495, 1938. Google Scholar2. LARSSON SO: Anemia and iron metabolism in hypothyroidism. Acta Med. Scand. 157: 349, 1957. CrossrefMedlineGoogle Scholar3. TUDHOPEWILSON GRGM: Anaemia in hypothyroidism: incidence, pathogenesis, and response to treatment. Quart. J. Med. 29: 513, 1960. MedlineGoogle Scholar4. AXELRODBERMAN ARL: The bone marrow in hyperthyroidism and hypothyroidism. Blood 6: 436, 1951. 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EVANSROSENBERGSIMPSON ESLLME: Erythropoietic response to calorigenic hormones. Endocrinology 68: 517, 1961. CrossrefMedlineGoogle Scholar24. DONATIWARNECKEGALLAGHER RMMANI: Ferrokinetics in hyperthyroidism. Ann. Intern. Med. 63: 945, 1965. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH M. KIELY, M.D., F.A.C.P.; DON C. PURNELL, M.D., F.A.C.P.; CHARLES A. OWENJR., M.D.Affiliations: Rochester, MinnesotaFrom the Section of Medicine and the Section of Clinical Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minn.This investigation was supported in part by research grant FR-5530, the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Joseph M. Kiely, M.D., Mayo Clinic, Rochester, Minn. 55901. 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HARRIS, M.D. 1 September 1967Volume 67, Issue 3_Part_1Page: 533-538KeywordsAnemiaClinical pathologyErythropoiesisHormonal therapyHypothyroidismIron deficiency anemiaPernicious anemiaRed blood cellsResearch grantsThyroid hormones ePublished: 1 December 2008 Issue Published: 1 September 1967 PDF downloadLoading ...