Reversal of the Nephrotic Syndrome by Colchicine in Amyloidosis of Familial Mediterranean Fever

Letters1 March 1992Reversal of the Nephrotic Syndrome by Colchicine in Amyloidosis of Familial Mediterranean FeverDeborah Zemer, MD, Avi Livneh, MD, Pnina Langevitz, MDDeborah Zemer, MD, Avi Livneh, MD, Pnina Langevitz, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-5-426_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Preventive long-term treatment with colchicine (using an appropriate daily dosage) may reduce kidney damage to minimal proteinuria in patients with familial mediterranean fever, even when it is introduced in the nephrotic stage of this amyloidotic renal disease. We are writing to correct our previous statement that colchicine does not affect amyloidotic kidney disease once it has reached the nephrotic stage (1). We report three cases in which colchicine treatment reduced such kidney damage.We treated a 40-year-old man of Jewish Sephardi origin who has had febrile attacks since the age of 6 months. In 1981, colchicine treatment,...References1. ZemerPrasSoharModanCabiliGafni DMEMSJ. Colchicine in the prevention and treatment of the amyloidosis of familial mediterranean fever. N Engl J Med. 1986;314:1001-5. CrossrefMedlineGoogle Scholar2. LivnehZemerSiegalLaorSoharPras ADBAEM. Colchicine prevents kidney-transplant amyloidosis in familial mediterranean fever. Nephron. [In press]. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. 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