Studies on the Antibiotic Therapy of Serious Staphylococcal Infections

Article1 February 1962Studies on the Antibiotic Therapy of Serious Staphylococcal InfectionsI. Comparison of the In Vitro Activity of Methicillin, Phenethicillin, and Other AntibioticsF. ROBERT FEKETY JR., M.D., LEIGHTON E. CLUFF, M.D.F. ROBERT FEKETY JR., M.D.Search for more papers by this author, LEIGHTON E. CLUFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-198 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHospital-acquired staphylococcal infections will continue as a serious problem so long as advances in medicine and surgery result in the prolongation of the lives of patients whose impaired resistance to infection remains unaltered. A guarded optimism for the future is justifiable in the light of rapidly increasing knowledge of the pathogenesis and epidemiology of staphylococcal infections and because of the development of new and effective antibiotics. There is general agreement that penicillin G is the ideal antistaphylococcal agent if the organism is sensitive to it (1, 2), but the saturation of hospitals with organisms which produce penicillinase has made sensitivity...References1. PETERSDORFROSEMINCHEWKEENEBENNETT RGMCHBWBIL: The sensitivity of hemolytic staphylococci to a series of antibiotics. Arch. Intern. Med. 105: 398, 1960. CrossrefMedlineGoogle Scholar2. MARTIN WJ: Clinical use of antimicrobial agents. Proc. Mayo Clin. 35: 593, 1960. MedlineGoogle Scholar3. MINCHEWCLUFF BHLE: Studies of the epidemiology of staphylococcal infection. J. Chron. Dis. 13: 354, 1961. CrossrefMedlineGoogle Scholar4. DINEEN P: A critical study of 100 consecutive wound infections. Surg. Gynec. Obstet. 113: 91, 1961. 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MCDERMOTT W: Microbial persistence. Yale J. Biol. Med. 30: 257, 1957-58. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, MarylandFrom the Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, Maryland.Supported by a contract between the United States Army Chemical Corps, Fort Detrick, Frederick, Maryland, and the Johns Hopkins University School of Medicine, Baltimore, Maryland.Requests for reprints should be addressed to F. Robert Fekety, Jr., M.D., The Johns Hopkins University School of Medicine, 601 N. Broadway, Baltimore 5, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByVancomycin RevisitedFRANCIS V. COOK, M.D., W. EDMUND FARRAR Jr., M.D., F.A.C.P.Combined therapy with cephalothin, kanamycin and colistin in patients with presumed bacteremiaPeritoneal dialysis in colistin intoxication: Report of a caseManagement of staphylococcal infectionsThe New PenicillinsThe Diagnosis and Treatment of Bacterial EndocarditisInfection of Man with MimeaeRICHARD C. REYNOLDS, M.D., LEIGHTON E. CLUFF, M.D., F.A.C.P.The Treatment of Gram-negative Bacillary Infections with Colistin The Toxicity and Efficacy of Large Doses in Forty-eight PatientsF. ROBERT FEKETY JR., M.D., PHILIP S. NORMAN, M.D., LEIGHTON E. CLUFF, M.D. 1 February 1962Volume 56, Issue 2Page: 198-206KeywordsAntibioticsEpidemiologyForecastingPathogenesisPenicillinStaphylococcal infectionStaphylococcusSurgery Issue Published: 1 February 1962 PDF DownloadLoading ...