The Physiologic and Clinical Significance of Erythropoietin

Article1 August 1958THE PHYSIOLOGIC AND CLINICAL SIGNIFICANCE OF ERYTHROPOIETINCLIFFORD W. GURNEY, M.D., LEON O. JACOBSON, M.D., F.A.C.P., EUGENE GOLDWASSER, Ph.D.CLIFFORD W. GURNEY, M.D.Search for more papers by this author, LEON O. JACOBSON, M.D., F.A.C.P.Search for more papers by this author, EUGENE GOLDWASSER, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-363 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntil recently it was generally agreed that low oxygen tension in the bone marrow constituted a direct stimulus for red cell production. This view was challenged by many investigators whose studies demonstrated that the rate of erythropoiesis, both in vivo1, 2 and in marrow cultures,3, 4 was independent of changes in oxygen tension. Clearly an alternate hypothesis was needed.In 1906 Carnot and Deflandre described the erythropoietic-stimulating properties of serum of anemic rabbits by injecting this serum into normal rabbits, thereby obtaining increased reticulocyte and hemoglobin values in the animals that received the anemic serum.5This experimental procedure was employed...Bibliography1. GrantRoot WCWS: The relation of oxygen in bone marrow blood to post-hemorrhagic erythropoiesis, Am. J. Physiol. 150: 618, 1947. CrossrefMedlineGoogle Scholar2. BerkBurchenalWoodCastle LJHTWB: Oxygen saturation of sternal marrow blood with special reference to pathogenesis of polycythemia vera, Proc. Soc. Exper. Biol. and Med. 69: 316, 1948. CrossrefMedlineGoogle Scholar3. RosinRachmilewitz AM: Studies on marrow in vitro. III. The effect of anoxia and hyperoxia on explanted bone marrow, Blood 3: 165, 1948. CrossrefMedlineGoogle Scholar4. Thomas ED: In vitro studies of erythropoiesis. II. The effect of anoxia on heme synthesis, Blood 10: 612, 1955. CrossrefMedlineGoogle Scholar5. CarnotDeflandre PC: Sur l'activite hemopoietique du serum, Compt. rend. Acad. d. sc. 143: 384, 1906. Google Scholar6. BorsookGraybielKeighleyWindsor HAGE: Polycythemic response in normal adult rats to a non-protein plasma extract from anemic rabbits, Blood 9: 734, 1954. CrossrefMedlineGoogle Scholar7. BonsdorffJalivisto EE: On the humoral mechanism in anoxic erythrocytosis, Acta physiol. Scandinav. 16: 150, 1948. CrossrefGoogle Scholar8. GrantRoot WCWS: Fundamental stimulus for erythropoiesis, Physiol. Rev. 32: 449, 1952. CrossrefMedlineGoogle Scholar9. Erslev AJ: Humoral regulation of red cell production, Blood 8: 349, 1953. CrossrefMedlineGoogle Scholar10. HodgsonToha GJ: The erythropoietic effect of urine and plasma of repeatedly bled rabbits, Blood 9: 299, 1954. CrossrefMedlineGoogle Scholar11. PlzakFriedJacobsonBethard LFWLOWF: Demonstration of stimulation of erythropoiesis by plasma from anemic rats using Fe59 , J. Lab. and Clin. Med. 46: 671, 1955. MedlineGoogle Scholar12. FriedPlzakJacobsonGoldwasser WLLOE: Erythropoiesis. II. Assay of erythropoietin in hypophysectomized rats, Proc. Soc. Exper. Biol. and Med. 92: 203, 1956. CrossrefMedlineGoogle Scholar13. FriedPlzakJacobsonGoldwasser WLFLOE: Studies on erythropoiesis. III. Factors controlling erythropoietin production, Proc. Soc. Exper. Biol. and Med. 94: 237, 1957. CrossrefMedlineGoogle Scholar14. PilieroMediciPanskyLuhbyGordon SJPTBALAS: Erythropoietic stimulating effects of plasma extracts from anemic human subjects, Proc. Soc. Exper. Biol. and Med. 93: 302, 1956. CrossrefMedlineGoogle Scholar15. LinmanBethell JWFH: The plasma erythropoietic stimulating factor. Observations on circulating erythrocytes and bone marrow of rats receiving protein-free extracts of rabbit plasma, Blood 11: 310, 1956. CrossrefMedlineGoogle Scholar16. JacobsonGoldwasserPlzakFried LOELFW: Studies on erythropoiesis. IV. Reticulocyte response of hypophysectomized and polycythemic rodents to erythropoietin, Proc. Soc. Exper. Biol. and Med. 94: 243, 1957. CrossrefMedlineGoogle Scholar17. GurneyGoldwasserPan CWEC: Studies on erythropoiesis. VI. Erythropoietin in human plasma, J. Lab. and Clin. Med. 50: 534, 1957. MedlineGoogle Scholar18. BethellLinmanKorst FHJWDR: Erythropoietic activity of "anemic" and "polycythemic" plasmas, Tr. A. Am. Physicians 70: 297, 1957. MedlineGoogle Scholar19. LinmanBethellLong JWFHMJ: Studies on the nature of the plasma erythropoietic factor(s), J. Lab. and Clin. Med. 51: 8, 1958. MedlineGoogle Scholar20. GoldwasserJacobsonFriedPlzak ELOWL: Mechanism of the erythropoietic effect of cobalt, Science 125: 1085, 1957. CrossrefMedlineGoogle Scholar21. GoldwasserJacobsonFriedPlzak ELOWLF: Studies on erythropoiesis. V. The effect of cobalt on the production of erythropoietin, Blood 13: 55, 1958. CrossrefMedlineGoogle Scholar22. Stohlman F: The utilization of erythropoietin, Clin. Research 6: 193, 1958. Google Scholar23. GurneyPan CWC: Studies on erythropoiesis. IX. Mechanism of decreased erythropoiesis in experimental polycythemia, Proc. Soc. Exper. Biol. and Med., in press. Google Scholar24. RobinsonJamesKark JCGWRM: The effect of oral therapy with cobaltous chloride on the blood of patients suffering with chronic suppurative infection, New England J. Med. 240: 754, 1949. CrossrefMedlineGoogle Scholar25. BerkBurchenalCastle LJHWB: Erythropoietic effect of cobalt in patients with or without anemia, New England J. Med. 240: 754, 1949. CrossrefMedlineGoogle Scholar26. ShanHamburger SCF: The anemia of cancer patients and its relation to metastases to the bone marrow, J. Lab. and Clin. Med. 37: 182, 1951. MedlineGoogle Scholar27. Gardner FH: The use of cobaltous chloride in anemia associated with chronic renal disease, J. Lab. and Clin. Med. 41: 56, 1953. MedlineGoogle Scholar28. WeinsaftBernstein PPLH: Treatment of certain refractory anemias, Am. J. M. Sc. 230: 264, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented at the Thirty-ninth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 30, 1958.From the Argonne Cancer Research Hospital, U. S. Atomic Energy Commission, and the Departments of Medicine and Biochemistry, The University of Chicago.Requests for reprints should be addressed to Clifford W. Gurney, M.D., 950 East Fifty-ninth Street, Chicago 37, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWhy is Erythropoietin Made in the Kidney?Losartan may modulate erythropoietin productionIron Therapy and the Anemia of ESRD: Historical PerspectiveOptimizing Epoetin Therapy in End-Stage Renal Disease: The Case for Subcutaneous AdministrationErythropoietin in the Anemia of End-Stage Renal DiseaseStatement on the Clinical Use of Recombinant Erythropoietin in Anemia of End-Stage Renal DiseaseHematological Problems of Dialysis PatientsHematologic Problems of Dialysis PatientsHematologic Problems of Dialysis PatientsHematologic Complications of Chronic Renal FailureThe Control of Red Cell ProductionERYTHROPOIETINErythropoietin and ErythropoiesisMedical management of chronic renal failureErythropoietinErythropoietin and ErythropoiesisCLIFFORD W. GURNEY, M.D.The Clinical Significance of Leukoerythroblastic AnemiaErythropoetin in der Schwangerschaft und nach der GeburtBeziehungen zwischen Erythropoetinaktivität des Blutes und Schweregrad der AnämieHydronephrosis and polycythemiaPRE-AZOTAEMIC RENAL ANAEMIA: A CLINICAL HYPOTHESIS SUPPORTED BY ANIMAL EXPERIMENTErythropoiesisHumoral Hematopoietic Factors in the Control of Erythrocyte ProductionREGULATION OF ERYTHROPOIESIS*Plasma Erythropoietin Levels in Anaemia: Studies Using an Assay Method in Intact RatsRenal PolycythemiaThe Regulation of Erythropoiesis as Studied with Isotopes: ErythropoietinZum Problem des ErythropoetinsAnemia of EndocrinopathiesFACTORS CONTROLLING HEMOPOIESIS: EXPERIMENTAL OBSERVATIONS ON THEIR ROLE IN POLYCYTHEMIA VERA*JAMES W. LINMAN, M.D., FRANK H. BETHELL, M.D., F.A.C.P., MARTHA J. LONG, M.S.STUDIES OF ERYTHROPOIETIN: THE HORMONE REGULATING RED CELL PRODUCTIONPolycythemia in Renal Carcinoma 1 August 1958Volume 49, Issue 2Page: 363-370KeywordsBlood plasmaBone marrowHemoglobinHormonesHospital medicineNephritisOxygenPolycythemiaRabbitsReticulocytes ePublished: 1 December 2008 Issue Published: 1 August 1958 PDF downloadLoading ...