Population
Mouse embryos, knock-out mutant mice for IGFBP-2 through -6, and wild-type litter mates.
Design
Preclinical
Authors
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Supports distinct endocrine vs. autocrine/paracrine IGFBP roles in mice; leaves open translation to human disease.
The study successfully generated specific antisera for mouse IGFBP-1 to -6, revealing distinct spatial localizations of mRNA and protein that suggest different functional mechanisms (endocrine vs. paracrine/autocrine) for the various binding proteins.
Kleffens et al. (1999) studied this question.
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