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July 1, 1999Molecular Endocrinology

Analysis of Functional Domains of Angiotensin II Type 2 Receptor Involved in Apoptosis

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Population

PC12 cells stably expressing mutated angiotensin II type 2 (AT2) receptors

Comparison

Mutated AT2 receptors with serial deletions or… vs Wild-type AT2 receptors or receptors with…

Design

Preclinical

Authors

JLJukka LehtonenLDLaurent DavietCNClara Nahmias

Discussion

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Overview

No immediate clinical implications for AT2 targeting; extends mapping of i3 loop residues critical for apoptosis in animal models.

Structured PICO

P
Population
PC12 cells stably expressing mutated angiotensin II type 2 (AT2) receptors
I
Intervention
Mutated AT2 receptors with serial deletions or alanine substitutions within the intracellular third loop (i3 loop), and a catalytically inactive SHP-1 mutant
C
Comparator
Wild-type AT2 receptors or receptors with deletions in the amino- or carboxyl-terminal portions of the i3 loop
O
Outcome
AT2-mediated apoptosis, inhibition of extracellular signal-regulated kinases (ERK), and SHP-1 activationsurrogate

The intermediate portion of the i3 loop of the AT2 receptor and proximal SHP-1 activation are critical for AT2-mediated apoptosis and ERK inhibition.

Cite This Study

Lehtonen et al. (1999) studied this question.

synapsesocial.com/papers/6a87d61d70098fa105bb5b9dhttps://doi.org/10.1210/mend.13.7.0303
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