Intercostal muscle from patients with myasthenia gravis and from 'control' patients without clinical signs of muscular disease was assayed for its acetylcholine content by means of gas chromatography/mass spectrometry. Apart from acetylcholine, no other similar compound was detected in the muscles. Myasthenic muscle contained about twice as much acetylcholine as control muscle, and the resting release of acetylcholine was approximately the same in both types of muscle.
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Ito et al. (1976) studied this question.
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