Why the study?
Although left atrial reduction benefits rhythm conversion, no study had investigated its efficacy compared with the Cox maze procedure for restoring atrial contractility in rheumatic mitral valve disease with atrial fibrillation.
Does the Cox maze IV procedure improve early sinus rhythm conversion and left atrial contractility restoration compared to left atrial reduction in patients with rheumatic mitral valve disease and atrial fibrillation?
Does the Cox maze IV procedure improve early sinus rhythm conversion and left atrial contractility restoration compared to left atrial reduction in patients with rheumatic mitral valve disease and atrial fibrillation?
While Cox maze IV is superior for early sinus rhythm conversion in rheumatic mitral valve disease, left atrial reduction is equally effective at restoring left atrial contractility in patients who achieve sinus rhythm.
Background The Cox maze procedure is the gold-standard concomitant surgical procedure to restore sinus rhythm in rheumatic mitral valve disease with atrial fibrillation. Left atrial reduction surgery was found to be beneficial for rhythm conversion, but no study has investigated its efficacy compared to the Cox maze procedure for atrial contractility restoration. We aimed to compare the early success rate of left atrial contractility restoration with the Cox maze procedure and left atrial reduction in rheumatic subjects. Methods Preoperative and within one-month postoperative electrocardiograms and echocardiograms of patients who underwent a Cox maze IV procedure or left atrial reduction with mitral valve surgery were compared. Effective atrial contraction was defined as A wave peak velocity ≥10 cm·s −1 or atrial filling fraction ≥20%. Results Ninety patients (mean age 40.6 ± 10.2 years, 66.7% female) were divided equally into group A (Cox maze IV) and group B (left atrial reduction). The early sinus rhythm conversion rate was 64.4% versus 24.4% ( p < 0.001) in groups A and B, respectively. In patients with restored sinus rhythm, contractility was restored in 41.4% and 36.4% ( p = 1.000). Postoperative left atrial volume index ≤76 mL·m −2 was an independent variable associated with early atrial contractility restoration in both groups (prevalence rate 0.97, p = 0.007). Conclusions In rheumatic subjects, the early sinus rhythm conversion rate was significantly higher after Cox maze IV compared to left atrial reduction, but for restoring left atrial contractility, left atrial reduction was not inferior to Cox maze IV.
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Firmansyah et al. (2019) studied this question.
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