Synthetic oxytocin injected rapidly, intravenously in 22 patients during elective cesarean section caused a decrease ill blood presslIre and an increase in heart rate. In 16 patients, heart rate, cardiac output, and stroke volume increased while mean arterial pressure and total peripheral resistance decreased. All changes were pronollllced, rapid in onset, and of short duration. No serious electrocardiographic changr;s were found. Repeat injeotion in 5 patients caused similar changes. The type of anesthesia did not appear to matter.
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Andersen et al. (1965) studied this question.