November 27, 2003Biochemistry

Glutamate 346 of Human Na⁺−H⁺ Exchanger NHE1 Is Crucial for Modulating both the Affinity for Na⁺ and the Interaction with Amiloride Derivatives

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Structured PICO

Population

Human Na+-H+ exchanger NHE1 (wild-type and NHE1-Glu(346)Asp mutant)

Intervention

Mutation of Glutamate 346 to Aspartate (Glu(346)Asp)

Comparator

Wild-type NHE1

Outcome

Sensitivity to inhibitors (HOE694 and EIPA) and affinity for Na+surrogate

Glutamate 346 in human NHE1 is crucial for its interaction with Na+ and inhibitors like HOE694 and EIPA.

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Highlights Glu346 as critical for NHE1 inhibitor sensitivity and Na+ affinity; hypothesis-generating for targeted therapies pending human validation.

Noël et al. (2003) studied this question.

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Highlights Glu346 as critical for NHE1 inhibitor sensitivity and Na+ affinity; hypothesis-generating for targeted therapies pending human validation.