Why the study?
Does nonenzymatic glycosylation of collagen increase normal platelet aggregation?
Does nonenzymatic glycosylation of collagen increase normal platelet aggregation?
Nonenzymatic glycosylation of collagen increases platelet aggregation, suggesting a potential mechanism for the increased thrombotic risk observed in diabetes.
May underlie increased thrombotic risk in diabetes; leaves open confirmation in human studies.
The effect of normal and nonenzymatically glycosylated rat type I acid-soluble collagen on normal human platelets was investigated. Glycosylated collagen was obtained either after in vitro incubation with glucose or from rats made diabetic by streptozotocin. The amount of nonenzymatically bound glucose was as follows: normal 2.3, diabetic 7.6 and in vitro glycosylated collagen 9.0 nmol/mg. When investigated under conditions leading to identical diameters and molecular packings for all the samples, the aggregation potency was markedly stronger for diabetic and glycosylated collagens than for normal ones. These results show the potential role of this posttranslational modification of collagen which can be considered as a risk factor in the thrombotic pathogeny of diabetes.
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Pape et al. (2009) studied this question.
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