Molecular characterization reveals intracellular localization of nine ABCC proteins in Leishmania, indicating that ABCC overexpression drives resistance to first-line antimonial treatments.
The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.
No takes yet. Share an insight, caveat, or question.
Leprohon et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: