Cimetidine-Theophylline Interaction

Letters and Corrections1 May 1982Cimetidine-Theophylline InteractionROBERT J. CLUXTON JR, PHARM.D., JOSÉ O. RIVERA, PHARM.D., WOLFGANG A. RITSCHEL, PH.D., AMADEO J. PESCE, PH.D., IRWIN B. HANENSON, M.D.ROBERT J. CLUXTON JR, PHARM.D.Search for more papers by this author, JOSÉ O. RIVERA, PHARM.D.Search for more papers by this author, WOLFGANG A. RITSCHEL, PH.D.Search for more papers by this author, AMADEO J. PESCE, PH.D.Search for more papers by this author, IRWIN B. HANENSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-5-684_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports have shown that cimetidine decreases theophylline clearance (1-3), and it is suggested that the decrease is caused by an inhibition of hepatic metabolism by cimetidine or its metabolites (2, 4). We report two cases that provide additional information on the reversibility and potential mechanism of this drug interaction.Patient 1:A 50-year-old black woman with a severe asthma attack was admitted to the medicine service on 1 July 1981. She had been discharged from the hospital on 25 June after treatment for upper gastrointestinal bleeding, for which cimetidine, 300 mg orally four times a day,...References1. CAMPBELL M, PLACHETKA J, JACKSON J, MOON J, and FINLEY P. Cimetidine decreases theophylline clearance. Ann Intern Med. 1981;95:68-9. LinkGoogle Scholar2. JACKSON J, POWELL J, and WANDELL J. Cimetidine decreases theophylline clearance. Am Rev Respir Dis. 1981;123:615-7. MedlineGoogle Scholar3. REITBERG D, BERNHARD H, and SCHENTAG J. Alteration of theophylline clearance and half-life by cimetidine. Ann Intern Med. 1981;95:582-5. LinkGoogle Scholar4. PUURUNEN J and PELKONEN O. Cimetidine inhibits microsmal drug metabolism in the rat: Eur J. Pharmacol. 1979;55:335-6. CrossrefMedlineGoogle Scholar5. ZOGLIO M and MAULDING H. Complexes of ergot alkaloids and derivatives. Interaction of dihydroergotoxine with certain xanthines. J Pharm Sci. 1970;59:215-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT J. CLUXTONJR, PHARM.D.; JOSÉ O. RIVERA, PHARM.D.; WOLFGANG A. RITSCHEL, PH.D.; AMADEO J. PESCE, PH.D.; IRWIN B. HANENSON, M.D.Affiliations: University of Cincinnati Medical Center Cincinnati, OH 45267 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug Interactions with Agents Used to Treat Gastrointestinal DiseaseDrug Interactions with Agents Used in Respiratory DiseaseConcerning drug interactions with theophyllineDrug interactions with cimetidine: An updateCimetidine-drug interactions 1 May 1982Volume 96, Issue 5Page: 684-684KeywordsAsthmaDrug interactionsHemorrhageMetabolites ePublished: 1 December 2008 Issue Published: 1 May 1982 PDF downloadLoading ...