Multiple system atrophy (MSA) is an adult-onset progressive neurodegenerative disorder that manifests clinically with autonomic failure, parkinsonism, and ataxia in any combination. Oligodendroglial cytoplasmatic inclusions consisting of misfoldedα-synuclein are a pathological hallmark of disease. The clinical diagnosisof MSA is typically delayed as a result of incomplete or nonspecific manifestations during early disease stages.
No takes yet. Share an insight, caveat, or question.
Stanković et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: