Assessment of anti-ARS autoantibodies like anti-OJ may facilitate the diagnosis and management of juvenile polymyositis, which can be effectively treated with intravenous cyclophosphamide when refractory to steroids.
May support cyclophosphamide in refractory juvenile polymyositis; leaves open anti-ARS testing utility in larger cohorts.
A 13-year-old girl was admitted for persistent thigh pain and remittent fever and was diagnosed as having juvenile polymyositis. Although the initial treatment with 2 cycles of methylprednisolone pulse therapy failed to achieve full remission, the second-line treatment with intravenous cyclophosphamide pulse therapy was effective. Anti-OJ antibody, which is one of anti-aminoacyl-tRNA synthetase (ARS) antibodies and is rare in adult polymyositis, was detected. Assessment of anti-ARS autoantibodies may facilitate diagnosis and management of juvenile polymyositis.
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Hamada et al. (2015) studied this question.
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