A toothpaste containing sodium fluoride and enzymes activating the anti-glycolytic lactoperoxidase-thiocyanate system was without inhibitory effects in 3 independent rat caries studies on formation of plaque, and smooth surface and fissure caries lesions when compared with a corresponding topical fluoride treatment. In contrast, topical hydrogen peroxide, mutanases, chlorhexidine and various fluoride dentifrices inhibited caries incidence significantly.
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Mühlemann et al. (2009) studied this question.