Dual Catalyst Control in the Amino Acid-Peptide-Catalyzed Enantioselective Baylis−Hillman Reaction

[reaction: see text] Nucleophile-loaded peptides and proline have been found to function synergistically as cocatalysts for the asymmetric ketone-based Baylis-Hillman reaction. Although neither compound is effective independently in terms of rate or enantioselectivity, their combination leads to catalysis where enantioselectivities up to 81% have been observed.