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September 1, 1989The Journal of Experimental MedicineOpen Access

Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain.

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Population

Model for Borna disease using a homogeneous T cell line NM1 with Borna disease virus reactivity

Design

Preclinical

Authors

JRJüergen A. RichtKansas State UniversityLSLothar StitzFriedrich-Loeffler-InstitutHWHartmut WekerleTokyo Institute of Technology

Discussion

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Overview

Implicates CD4+ T cells in Borna disease meningoencephalomyelitis; leaves open applicability beyond this animal model.

Structured PICO

P
Population
Model for Borna disease (progressive meningoencephalomyelitis) using a homogeneous T cell line NM1 with Borna disease virus reactivity
I
Intervention
Adoptive transfer of NM1 CD4+ T cells
O
Outcome
Immunopathological effect leading to Borna disease

CD4+ T cells are responsible for the immunopathological effect leading to progressive meningoencephalomyelitis in Borna disease.

Cite This Study

Richt et al. (1989) studied this question.

synapsesocial.com/papers/6a87f1eecb36de311aaa61cehttps://doi.org/10.1084/jem.170.3.1045
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis1981 · 919 citations
  2. 2Further Studies of a Simian Virus 40-Like Virus Isolated from Human Brain1972 · 43 citations
  3. 3Pathogenesis of Infection with Human Immunodeficiency Virus1987 · 499 citations
  4. 4Detection of Serum Antibodies to Borna Disease Virus in Patients with Psychiatric Disorders1985 · 314 citations
  5. 5Purification and Properties of an Intranuclear Virus-specific Antigen from Tissue Infected with Borna Disease Virus1986 · 97 citations