The infant rabbit model, developed to study human ETEC with CFA/I (Evans et al., 1975), was used to evaluate agarose (Sepharose) gel substituted with a hydrophobic ligand for prevention of diarrhoeal symptoms. In a group of rabbits given 0.02 g of palmitoyl Sepharose 1 h after an oral infection with 10(9) ETEC organisms with CFA/I antigen, only 2/11 animals developed diarrhoea, while in control groups given the unsubstituted Sepharose (hydrophilic) gel or ETEC organisms alone, all animals developed diarrhoea. In groups of rabbit given the hydrophobic gel 6 h after the ETEC organisms, only 2/6 animals showed a short period of diarrhoea. The "hydrophobic principle" to prevent ETEC infections will be studied in other animal models and in human volunteers.
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Wadström et al. (1981) studied this question.
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