Why the study?
Does inhaled amyl nitrite cause profound bradycardia in patients with a tendency to vasovagal episodes?
Does inhaled amyl nitrite cause profound bradycardia in patients with a tendency to vasovagal episodes?
Amyl nitrite administration during diagnostic echocardiography can trigger paradoxical profound bradycardia and syncope in patients prone to vasovagal episodes.
May trigger profound bradycardia in vasovagal-prone patients during echocardiography; hypothesis-generating, should not yet change practice.
Two patients with mild aortic insufficiency inhaled amyl nitrite during routine echocardiographic examinations. One developed sinus arrest and syncope and the other had pronounced sinus bradycardia. The mechanism of this paradoxical response is unclear. Caution should be exercised when amyl nitrite is administered for diagnostic purposes.
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Rosoff et al. (1986) studied this question.
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