Population
Rabbit mesenteric arterial strips
Comparison
Sulfhydryl reagents vs Baseline responses without sulfhydryl reagents
Design
Preclinical
Authors
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Supports mechanistic studies of vascular Ca2+ channels in animal models; leaves open translation to human arteries or in vivo conditions.
Reduction of disulfide bridges to sulfhydryl groups at Ca2+-channels increases transmembrane Ca2+ influx, potentiating contractile responses to various agonists in rabbit mesenteric arteries.
Asano et al. (1983) studied this question.
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