Why the study?
What is the mechanism of Wenckebach-Luciani cycles during atrial or ventricular stimulation in a denervated dog heart model?
Population
Dogs anesthetized with pentobarbital, with the heart denervated, the S.A. node crushed, and the adrenals…
Design
Preclinical
Authors
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Challenges cumulative impairment hypothesis in denervated dog hearts; leaves open translation to human conduction.
What is the mechanism of Wenckebach-Luciani cycles during atrial or ventricular stimulation in a denervated dog heart model?
Wenckebach cycles arise from the modulation between stimulus frequency and the longest functional refractory period of the conducting system, challenging the cumulative impairment hypothesis.
A. Rosenblueth (1958) studied this question.
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