Cerebral Malaria

Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria. Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria. Cerebral malaria (CM) is a severe and potentially fatal neurological manifestation of infection with Plasmodium species. P. falciparum, the major causative agent of human CM, accounts annually for approximately one million deaths of children in Sub-Saharan Africa alone.1Desruisseaux M.S. Machado F.S. Weiss L.M. Tanowitz H.B. Golightly L.M. Cerebral malaria: a vasculopathy.Am J Pathol. 2010; 176: 1075-1078Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar Despite effective antimalarial therapy, surviving individuals with CM may develop long-term neurological deficits,2Desruisseaux M.S. Gulinello M. Smith D.N. Lee S.C. Tsuji M. Weiss L.M. Spray D.C. Tanowitz H.B. Cognitive dysfunction in mice infected with Plasmodium berghei strain ANKA.J Infect Dis. 2008; 197: 1621-1627Crossref PubMed Scopus (46) Google Scholar, 3Newton C.R. Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment.Pharmacol Ther. 1998; 79: 1-53Crossref PubMed Scopus (280) Google Scholar, 4Lou J. Lucas R. Grau G.E. 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Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment.Pharmacol Ther. 1998; 79: 1-53Crossref PubMed Scopus (280) Google Scholar has despite their for studies of Grau G.E. and in the pathogenesis of cerebral in Full Text Full Text PDF PubMed Scopus Google Scholar with to in of infected and these studies to of their and and C.R. Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment.Pharmacol Ther. 1998; 79: 1-53Crossref PubMed Scopus (280) Google Scholar, C. of is not a 2008; 14: PubMed Scopus Google Scholar, J. P. M. M. J. M. P. The of and malaria for J. PubMed Scopus Google Scholar with studies on present a of C.R. Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment.Pharmacol Ther. 1998; 79: 1-53Crossref PubMed Scopus (280) Google Scholar, 4Lou J. Lucas R. Grau G.E. 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The that this not the the to the and that from CM have been in seminal in understanding of this of and to that The present review on the of dysfunction in CM, that this and possible of children in Sub-Saharan Africa most to R.O. S. M. The of fatal cerebral malaria in J Pathol. Full Text Full Text PDF PubMed Scopus Google Scholar is associated with a of R.O. S. M. The of fatal cerebral malaria in J Pathol. Full Text Full Text PDF PubMed Scopus Google Scholar CM that in CM, is severe and neurological R.O. S. M. The of fatal cerebral malaria in J Pathol. Full Text Full Text PDF PubMed Scopus Google Scholar is the of P. falciparum and with of falciparum malaria of the of and Scholar The of CM is of the of disease. The of parasite in is a of is a of a of neurological M.J. N. in children with cerebral J 2010; Full Text Full Text PDF PubMed Scopus (46) Google Scholar the has one of the of both and M.J. 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