The Radiothyroxine Turnover Study in the Diagnosis of Thyroid Disease

Article1 June 1966The Radiothyroxine Turnover Study in the Diagnosis of Thyroid DiseaseGERALD BURKE, M.D.GERALD BURKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1208 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe disappearance curve of plasma radioactivity after the intravenous injection of131I-labeled 1-thyroxine has been utilized experimentally to determine the magnitude and turnover of the exchangeable thyroid hormonal pool in man (1-4). This report is concerned with theclinicalapplication of the determination of radiothyroxine turnover to the characterization of thyroid function in patients with suspect thyroid disease in whom conventional (that is, routine) thyroid function studies had not allowed a definitive diagnosis. The results obtained demonstrate the value of a radiothyroxine turnover study in these circumstances and suggest that the rate of removal of circulating thyroxine is a significant...References1. HAMOLSKYFREEDBERGKURLANDWOLSKY MWASGSL: The exchangeable thyroid hormonal pool. I. Its magnitude and rate of turnover in various thyroid states in man. J. Clin. Invest. 32: 453, 1953. CrossrefMedlineGoogle Scholar2. BERSONYALOW SARS: Quantitative aspects of iodine metabolism. The exchangeable organic iodine pool and the rate of thyroidal secretion, peripheral degradation and fecal excretion of endogenously synthesized organically bound iodine. J. Clin. Invest. 33: 1533, 1954. CrossrefMedlineGoogle Scholar3. INGBARFREINKEL SHN: Simultaneous estimation of rates of thyroxine degradation and thyroid hormone synthesis. J. Clin. Invest. 34: 808, 1955. CrossrefMedlineGoogle Scholar4. STERLINGCHODOS KRB: Radiothyroxine turnover studies in myxedema, thyrotoxicosis and hypermetabolism without endocrine disease. J. Clin. Invest. 35: 806, 1956. CrossrefMedlineGoogle Scholar5. ESCOBAR DEL REYMORREALE DE ESCOBAR FG: The effect of propylthiouracil, methylthiouracil and thiouracil on the peripheral metabolism of 1-thyroxin in thyroidectomized, 1-thyroxin maintained rats. Endocrinology 69: 456, 1961. CrossrefMedlineGoogle Scholar6. SLINGERLANDBURROWS DWBA: Inhibition by propylthiouracil of the peripheral metabolism of radiothyroxine. J. Clin. Endocr. 22: 511, 1962. CrossrefGoogle Scholar7. HERSHMAN JM: Effect of 5- and 6-propylthiouracil on the metabolism of 1-thyroxine in man. J. Clin. Endocr. 24: 173, 1964. CrossrefGoogle Scholar8. BARKERHUMPHREYSOLEY SBMJMH: The clinical determination of protein-bound iodine. J. Clin. Invest. 30: 55, 1951. CrossrefMedlineGoogle Scholar9. GROSSMANGROSSMAN AGF: Protein-bound iodine by alkaline incineration and a method for producing a stable cerate color. J. Clin. Endocr. 15: 354, 1955. CrossrefGoogle Scholar10. NEWBURGERSILVERYOHALEMFEITELBERG RASSBS: Uptake and blood level of radioactive iodine in hyperthyroidism. New Eng. J. Med. 253: 127, 1955. CrossrefMedlineGoogle Scholar11. WERNERSPOONER SCM: A new and simple test for hyperthyroidism employing 1-triiodothyronine and the twenty-four hour I131 uptake method. Bull. N. Y. Acad. Med. 31: 137, 1955. MedlineGoogle Scholar12. MITCHELLHARDENO'ROURKE MLABME: The in vitro resin sponge uptakes of triiodothyronine-I131 from serum in thyroid disease and pregnancy. J. Clin. Endocr. 20: 1474, 1960. CrossrefMedlineGoogle Scholar13. BURKEMETZGERGOLDSTEIN GBEMS: Routine clinical application of an electrophoretic method for characterizing thyroid function. J. Lab. Clin. Med. 63: 708, 1964. MedlineGoogle Scholar14. BURKEGOLDSTEIN GMS: Routine clinical application of an electrophoretic method for characterizing thyroid function; comparison with other in-vitro techniques. Fed. Proc. 23: 107, 1964. Google Scholar15. ENGBRINGENGSTROM NHWW: Effects of estrogen and testosterone on circulating thyroid hormone. J. Clin. Endocr. 19: 783, 1959. CrossrefMedlineGoogle Scholar16. SOLEYMILLERFOREMAN MHERN: Graves' disease: treatment with radioactive iodine (I131). J. Clin. Endocr. 9: 29, 1949. CrossrefGoogle Scholar17. WERNERQUIMBYSCHMIDT SCEHC: The use of tracer doses of radioactive iodine (I131) in the study of normal and disordered thyroid function in man. Ibid., p. 342. Google Scholar18. WERNER SC: Response to triiodothyronine as index of persistence of disease in the thyroid remnant of patients in remission from hyperthyroidism. J. Clin. Invest. 35: 57, 1956. CrossrefMedlineGoogle Scholar19. INGBARFREINKEL SHN: Studies of thyroid function and the peripheral metabolism of I131-labeled thyroxine in patients with treated Grave's disease. J. Clin. Invest. 37: 1603, 1958. CrossrefMedlineGoogle Scholar20. LEEBRONSKYWALDSTEIN WYDSS: Studies of thyroid and sympathetic nervous system interrelationships. II. Effects of guanethidine on manifestations of hyperthyroidism. J. Clin. Endocr. 22: 879, 1962. CrossrefMedlineGoogle Scholar21. SILVER S: Radioactive Isotopes in Medicine and Biology, 2nd ed. Lea & Febiger, Philadelphia, 1962, p. 71. Google Scholar22. BURNETTVAN BURENFALOON GRHCWW: Low serum PBI values with clinical euthyroidism in I131 treated thyrotoxicosis. JAMA 181: 99, 1962. CrossrefMedlineGoogle Scholar23. ROBBINSRALLPETERMANN JJEML: Thyroxine-binding by serum and urine proteins in nephrosis. Qualitative aspects. J. Clin. Invest. 36: 1338, 1957. CrossrefGoogle Scholar24. ROSENBERGAHNMITCHELL INCSML: Effects of anabolic steroids upon circulating thyroid hormones. J. Clin. Endocr. 22: 612, 1962. CrossrefGoogle Scholar25. OPPENHEIMERFISHERNELSONJAILER JHLVKMJW: Depression of the serum protein-bound iodine level by diphenylhydantoin. J. Clin. Endocr. 21: 252, 1961. CrossrefMedlineGoogle Scholar26. BURKE G: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GERALD BURKE, M.D.Affiliations: Chicago, IllinoisFrom the Radioisotope Laboratory, Department of Metabolism and Endocrinology, Division of Medicine, Michael Reese Hospital and Medical Center, Chicago, Ill.Requests for reprints should be addressed to Gerald Burke, M.D., Radioisotope Laboratory, Michael Reese Hospital and Medical Center, Chicago, Ill. 60616.*Approximately 50 μc in 2 to 10 μg thyroxine supplied by Abbott Laboratories, Oak Ridge, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTriiodothyronine turnover studies in euthyroid patients with autonomous thyroid nodulesHematology, blood chemistry and protein polymorphisms in the white-tailed deer (Odocoileus virginianus)Occult Factitial Thyrotoxicosis Thyroxine Kinetics and Psychological Evaluation in Three CasesEDWARD ROSE, M.D., F.A.C.P., THEODORE P. SANDERS, M.D., WILLIAM L. WEBB JR., M.D., RALPH C. HINES, M.D.The triiodothyronine suppression test 1 June 1966Volume 64, Issue 6Page: 1208-1220KeywordsBiologicsEndocrinologyEstrogensHospital medicineIntravenous injectionsResearch laboratoriesThyroidThyroid diseasesThyroid hormonesThyroxine ePublished: 1 December 2008 Issue Published: 1 June 1966 PDF downloadLoading ...