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Previous reports that cortisone and related compounds exerted a small degree of protection against antigen-aerosol-induced anaphylactic reactions, have been confirmed. Optimal effects were obtained 16 to 24 h after corticosteroid pretreatment. Marked effects were obtained from the more potent glucocorticoids, particularly water-soluble compounds. Similar pretreatment decreased the severity and modified the form of anaphylactic bronchoconstrictor responses induced by intravenous administration of antigen. In guinea-pigs pretreated also with mepyramine, the corticosteroids suppressed the residual and presumably non-histamine component of the anaphylactic bronchoconstrictions. Anti-anaphylactic potency was correlated with glucocorticoid and anti-inflammatory activity. A suggested mode of action involves a combination of weak anti-histamine activity and inhibition of release of slow reacting substances of anaphylaxis.
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R. Hicks (1970) studied this question.
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