The permeability effects of topical and intravenous prostaglandin E₂ (PGE₂) and 16, 16-dimethyl prostaglandin E₂ (16DM) were studied in canine Heidenhain pouches using an acid-free perfusate, and changes in volume and HCO-₃ content of the perfusate were measured. Topical and intravenous 16DM increased the apparent flux of Na+ and Cl-, and stimulated the secretion of fluid containing HCO-₃. 16DM stimulates non-parietal cell secretion and therefore the movement of Na+ cannot be interpreted as passive flux in response to changes in permeability.
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Bolton et al. (2009) studied this question.