Why the study?
Does MMP inhibition prevent cardiac hypertrophy induced by beta-adrenergic stimulation in rats?
Population
Rats infused with isoproterenol (3 mg/kg per day)
Design
Preclinical
Authors
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Supports MMP-IGF axis in rat hypertrophy models; leaves open translation to human disease.
Does MMP inhibition prevent cardiac hypertrophy induced by beta-adrenergic stimulation in rats?
MMP inhibition prevents isoproterenol-induced cardiac hypertrophy in rats by modulating the IGF-I axis.
Miura et al. (2003) studied this question.
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