Effect of naloxone, a specific opioid inhibitor, on blood pressure fall during sleep.
Why the study?
Does naloxone prevent the fall in blood pressure during initial sleep in normal men?
Population
7 normal men, ages 20-30 years
Comparison
Naloxone 0.2 mg/kg infusion over 1 minute vs Volume-matched saline (placebo)
Design
RCT, randomized order
Follow-up
first 4 hours of non-rapid eye movement sleep
Authors
Discussion
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Implication
Naloxone prevents normal systolic BP decline at sleep onset; confirms endogenous opioid mediation and extends mechanistic research on nocturnal BP regulation.
Structured PICO
Does naloxone prevent the fall in blood pressure during initial sleep in normal men?
P
Population
7 normal men, ages 20-30 years
I
Intervention
Naloxone 0.2 mg/kg infusion over 1 minute
C
Comparator
Volume-matched saline (placebo)
O
Outcome
Change in systolic blood pressure during the first 4 hours of non-rapid eye movement sleepsurrogate
Naloxone prevents the physiological fall in systolic blood pressure during initial sleep, suggesting endogenous opioids mediate this response.
Cite This Study
Rubin et al. (1981) studied this question.