It was recently discovered that the CRY protein in Drosophila is a photoreceptor that detects extrinsic light stimuli and is a crucial player in maintaining the circadian rhythm of the fruit fly. Subsequently, it was presumed that the CRY proteins in mice also subserve the same function. Now, [Paul Hardin and Nicholas Glossop][1] in a Perspective, relates the surprising finding that the CRYS of mice are not circadian photoreceptors but instead serve as inhibitors in the endogenous oscillator itself ([ Okamura et al. ][2]). [1]: http://www.sciencemag.org/cgi/content/full/286/5449/2460 [2]: http://www.sciencemag.org/cgi/content/short/286/5449/2531
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Hardin et al. (1999) studied this question.
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