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The preparation of 2,4-disubstituted imidazoles from the condensation of α-haloketones with amidines is described. The optimal reaction protocol is to add the α-bromoketone solution to the amidine in aqueous tetrahydrofuran in the presence of potassium bicarbonate under vigorous reflux. Imidazole was isolated in 83−91% yield with >95% purity without column chromatography.
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Li et al. (2002) studied this question.
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