Hepatotoxicity Implies Chemical-Driven Liver Damage Induced By Certain Medicinal and Other Chemical Agents

There are increasing evidences that free radicals and reactive oxygen species play a crucial role in the various steps that initiate and regulate the progression of liver diseases. Oxidative stress in hepato-toxicity resulting from increased generation of reactive oxygen species (ROS) and other reactive intermediates as well as by decreased efficiency of antioxidant defenses actively contributes to excessive tissue remodeling. Drug-induced nephropathy is reported to be the third most common cause of acute renal failure in hospitalized patients. Excess ROS production and depressed antioxidant defence mechanism are responsible for nephrotoxicity.So, pharmacological studies in this work were done to evaluate: presence of protective effects of an antioxidant Hesperedine on carbon tetrachlorideinduced hepatic toxicity and nephro-toxicity, to evaluate its effects on oxidants and antioxidants parameters and to evaluate its effect on kidney and liver functions and histo-pathological changes.Liver enzymes level AST and ALT : was increased significantly in rats treated with CCl4 but decreased significantly in rats treated with antioxidant HDN (100 mg/ kg/ day) and in rats treated with antioxidant HDN (200 mg/ kg/ day) . in comparison between antioxidant treated rats groups liver enzymes level was decreased significantly in rats treated with antioxidant HDN (200 mg/ kg/ day) than in rats treated with antioxidant HDN (100 mg/ kg/ day) .Serum creatinine level: was increased insignificantly in rats treated with CCl4 but decreased insignificantly in rats treated with antioxidant HDN (100 mg/ kg/ day) and in rats treated with antioxidant HDN (200 mg/ kg/ day). in comparison between antioxidant treated rats groups liver enzymes level was decreased insignificantly in rats treated with antioxidant HDN (200 mg/ kg/ day) than in rats treated with antioxidant HDN (100 mg/ kg/ day) . So, we recommend uses of antioxidant Hesperedine as it has a valuable role in improvement of liver functions and as a prophylactic of hepatic and renal tissues against toxicity achieved by free radicals.