The effect of Syrijet applied disodium cromoglycate (DSCG) on mast cell degranulation and on gingivitis was investigated in rhesus monkeys. Mast cell counts were obtained by tracing representative areas from specially stained tissue sections and visually counting mast cells per unit area. Results revealed that while the drug inhibited mast cell degranulation, this was not associated with any detectable change in gingivitis in the time period studied. D.S.C.G. should provide an invaluable tool for the continued investigation of the role of mast cells in gingivitis.
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Nuki et al. (1975) studied this question.
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