Regulation of cellular calcium through signaling cross‐talk involves an intricate interplay between the actions of receptors, G‐proteins, and second messengers

Various external stimuli regulate cellular Ca 2+ fluxes. Information from these stimuli is transmitted to the cell interior by signal transducing systems that involve interactions between receptors, G‐proteins, and enzymes that generate second messengers. The possible mechanisms by which “crosstalk” within and between these second messenger‐ generating systems provides an intricate molecular avenue for fine modulation of intracellular Ca 2+ are reviewed.—Bygrave, F. L., Roberts, H. R. Regulation of cellular calcium through signaling cross‐talk in‐volves an intricate interplay between the actions of receptors, G‐proteins, and second messengers. FASEB J. 9, 1297‐1303 (1995)