Why the study?
Does the time to diagnosis correlate with tumor stage in patients with Ewing's sarcoma?
Does the time to diagnosis correlate with tumor stage in patients with Ewing's sarcoma?
In Ewing's sarcoma, a longer time to diagnosis is not associated with a more advanced tumor stage, and metastatic disease is often diagnosed earlier, possibly due to more aggressive biological behavior.
Delays in Ewing sarcoma diagnosis should not guide staging expectations; leaves open tumor biology as driver of earlier metastatic detection.
The relationship between tumor stage and time to diagnosis was investigated in a consecutive series of 618 patients with Ewing's sarcoma. This tumor is diagnosed late, with a mean interval between initial symptoms and biopsy of 4 months. The interval between the clinical onset and the final diagnosis was not associated with tumor stage. On the contrary, patients with metastatic Ewing's sarcoma were generally diagnosed at an earlier time than patients with localized disease, possibly reflecting inherent biological differences in aggressiveness among sub-groups of Ewing's sarcoma.
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Bacci et al. (1999) studied this question.