Clozapine treatment in a patient with treatment-resistant schizophrenia allowed for successful pregnancy and delivery of a healthy baby, though complicated by gestational diabetes.
Supports clozapine continuation in pregnancy for refractory schizophrenia; hypothesis-generating and should not yet change practice.
The authors describe the case of a patient with treatment-resistant schizophrenia who became pregnant after switching from conventional neuroleptic medications to clozapine, an atypical antipsychotic medication that does not cause hyperprolactinemia. Gestational diabetes, possibly exacerbated by clozapine, complicated management of her pregnancy. Comprehensive community support and psychiatric rehabilitation, combined with a positive response to clozapine, contributed to satisfying the patient's goal of having a healthy baby and being able to take the baby home to live with her and her husband.
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Dickson et al. (1998) studied this question.
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