Key result
N,N-disubstituted dithiocarbamates act as potent inhibitors of human carbonic anhydrase isoforms I, II, and IX, with inhibition constants ranging from subnanomolar to micromolar levels.
Dithiocarbamates are a novel class of potent carbonic anhydrase inhibitors that bind the zinc ion in a monodentate manner, showing subnanomolar efficacy against key human isoforms.
No takes yet. Share an insight, caveat, or question.
Dithiocarbamates merit preclinical cardiovascular testing; leaves open clinical utility as carbonic anhydrase inhibitors.
Carta et al. (2011) studied this question. Dithiocarbamates (DTCs) vs. Acetazolamide was evaluated on Inhibition constant (KI) against hCA I, II, and IX. N,N-disubstituted dithiocarbamates act as potent inhibitors of human carbonic anhydrase isoforms I, II, and IX, with inhibition constants ranging from subnanomolar to micromolar levels.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: