Dann et al. (1) tested immune responses of volunteers exposed to Cryptosporidium oocysts using an enzyme-linked immunosorbent assay (ELISA). They found fecal immunoglobulin A (IgA) but no serum IgG2 response to infection. They concluded that in the naive individual, the parasite elicits a strong secretory antibody response but fails to provide adequate immune stimulation for serum antibody detectable by ELISA.
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Muller et al. (2001) studied this question.
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