Key result
Ivabradine at 0.6 mg/kg reduced oxidative stress and improved renal function markers in rats with renal ischemia-reperfusion injury, whereas a 6 mg/kg dose worsened oxidative stress.
Why the study?
Does ivabradine reduce renal ischemia-reperfusion injury in a rat model?
Does ivabradine reduce renal ischemia-reperfusion injury in a rat model?
Ivabradine demonstrates a dose-dependent protective effect against renal ischemia-reperfusion injury in rats at 0.6 mg/kg, but loses this protective effect at a higher dose of 6 mg/kg.
No takes yet. Share an insight, caveat, or question.
Low-dose ivabradine may protect rat kidneys from IRI; leaves open translation and optimal dosing for human ischemia-reperfusion injury.
Beytur et al. (2011) studied Renal ischemia-reperfusion (I/R) injury. Ivabradine vs. Control and I/R without treatment was evaluated on Tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) contents, and serum BUN and creatinine. Ivabradine at 0.6 mg/kg reduced oxidative stress and improved renal function markers in rats with renal ischemia-reperfusion injury, whereas a 6 mg/kg dose worsened oxidative stress.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: