Procyanidins (PCs), as the second most abundant natural phenolic compounds on earth, have gained much attention due to their various health promoting effects. However, the proven benefits of PCs have some stability and bioavailability issues. Nano drug delivery systems are proposed to improve their pharmacokinetic profiles, including stability and bioavailability problems. The proper process about making nano-PCs can enhance the solubility of polymeric procyanidins (PPCs) and protect oligomeric procyanidins (OPCs) from degradation. This review provides a systematic summary of health benefits of PCs and the advanced nanotechnology to improve adsorption and bioavailability of PCs, which in turn would be helpful in increasing their therapy efficacy.
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Hou et al. (2021) studied this question.
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