Cefoxitin-Resistant Facultative or Aerobic Gram-Negative Bacilli in Infections Associated with the Gastrointestinal Tract

Article1 April 1981Cefoxitin-Resistant Facultative or Aerobic Gram-Negative Bacilli in Infections Associated with the Gastrointestinal TractALFRED J. SAAH, M.D., GEORGE L. DRUSANO, M.D., JOHN W. WARREN, M.D., JAMES H. TENNEY, M.D., ELLIS S. CAPLAN, M.D.ALFRED J. SAAH, M.D.Search for more papers by this author, GEORGE L. DRUSANO, M.D.Search for more papers by this author, JOHN W. WARREN, M.D.Search for more papers by this author, JAMES H. TENNEY, M.D.Search for more papers by this author, ELLIS S. CAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-4-487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfections associated with the gastrointestinal tract, such as intra-abdominal abscesses, are usually caused by a mixture of facultative or aerobic gram-negative bacilli and anaerobic organisms, particularlyBacteroides fragilis(1). Cefoxitin, a newly introduced cephalosporin-like antibiotic, has a broad spectrum of activity against aerobic gram-negative rods (2) and anaerobic bacteria including theB. fragilisgroup (3). Because of this range of activity, cefoxitin has been viewed as potentially useful as a single antibiotic in treating mixed aerobic-anaerobic infections of the abdomen (4). Indeed, in a rat model of abdominal abscesses, the effect of cefoxitin alone was equivalent to that of the...References1. GORBACHBARTLETT SJ. Anerobic infections. N Engl J Med. 1974;290:1177-84, 1237-45, 1289-94. CrossrefMedlineGoogle Scholar2. MOELLERINGDRAYKUNZ RML. Susceptibility of clinical isolates of bacteria to cefoxitin and cephalothin. Antimicrob Agents Chemother. 1974;6:320-3. CrossrefMedlineGoogle Scholar3. SUTTERFINEGOLD VS. Susceptibility of anaerobic bacteria to carbenicillin, cefoxitin, and related drugs. J Infect Dis. 1975;131:417-22. CrossrefMedlineGoogle Scholar4. GEDDESSCHNURRBALL ALA. Cefoxitin: a hospital study. Br Med J 1977;1:1126-8. CrossrefMedlineGoogle Scholar5. LOUIEONDERDONKGORBACHBARTLETT TASJ. Therapy for experimental intra-abdominal sepsis: comparison of four cephalosporins with clindamycin plus gentamicin. J Infect Dis. 1977;135S:S18-22. CrossrefGoogle Scholar6. SUTTERBARRYWILKINSZABRANSKY VATR. Collaborative evaluation of a proposed reference dilution method of susceptibility testing of anaerobic bacteria. Antimicrob Agents Chemother. 1979;16:495-502. CrossrefMedlineGoogle Scholar7. ONDERDONKKASPERCISNEROSBARTLETT ADRJ. The capsular polysaccharide of Bacteroides fragilis as a virulence factor: comparison of the pathogenic potential of encapsulated and unencapsulated strains. J Infect Dis. 1977;136:82-9. CrossrefMedlineGoogle Scholar8. DUPONTSPINK HW. Infections due to gram-negative organisms: an analysis of 860 patients with bacteremia at the University of Minnesota Medical Center, 1958-1966. Medicine (Baltimore). 1969;48:307-32. CrossrefMedlineGoogle Scholar9. HARRISCOBBX JC. Persistent gram-negative bacteremia: observations in twenty patients. Am J Surg. 1973;125:705-17. CrossrefMedlineGoogle Scholar10. WEINSTEINONDERDONKBARTLETTGORBACH WAJS. Experimental intraabdominal abscesses in rats: development of an experimental model. Infect Immun. 1974;10:1250-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Maryland School of Medicine Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRole of aminoglycoside antibiotics in the treatment of intra-abdominal infectionAlterations in human fecal flora, including ingrowth of Clostridium difficile, related to cefoxitin therapy 1 April 1981Volume 94, Issue 4_Part_1Page: 487-488KeywordsAbscessesAnaerobic bacteriaAntibioticsBacteroidesGastrointestinal infectionsGastrointestinal tractInfectious diseasesRat models Issue Published: 1 April 1981 PDF DownloadLoading ...