Nickel blocks L-type calcium channels in guinea pig ventricular myocytes, and this block is significantly altered by internal cAMP, suggesting that calcium channel phosphorylation induces conformational changes affecting nickel binding.
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Ni block of I(Ca,L) varies with cAMP; leaves open relevance to human myocytes or in vivo models.
Hobai et al. (2000) studied this question.
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